Medication-Assisted Treatment

Buprenorphine + Naloxone (Suboxone/Zubsolv) Treatment

Information on buprenorphine/naloxone as a medication-assisted treatment for opioid use disorder at Keystone Health Group in Los Angeles.

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Buprenorphine/naloxone (brand names Suboxone and Zubsolv) is the most widely used FDA-approved medication for opioid use disorder. It combines buprenorphine — a partial opioid agonist that reduces withdrawal symptoms and cravings — with naloxone, an opioid antagonist included to deter injection misuse. At Keystone Health Group, buprenorphine/naloxone is used as part of our comprehensive medication-assisted treatment program for opioid use disorder.

How Buprenorphine/Naloxone Works

Buprenorphine is a partial agonist at the mu-opioid receptor — it activates opioid receptors but with a ceiling effect, producing less euphoria and respiratory depression than full agonists like heroin or oxycodone. This ceiling effect makes it significantly safer in terms of overdose risk. Buprenorphine's long half-life (24–72 hours) provides stable, sustained relief from withdrawal symptoms and cravings with once-daily dosing.

Short-Term vs. Long-Term Use

Buprenorphine/naloxone can be used in two ways: as a short-term aid during detox (typically 7–14 days), or as long-term maintenance therapy (months to years) to prevent relapse. Research consistently shows that longer-term MAT produces better outcomes than short-term detox alone. Our physicians work with each client to determine the appropriate duration of treatment.

Addressing Stigma Around MAT

Some people — and some treatment programs — view MAT as 'substituting one drug for another.' This perspective is not supported by evidence. MAT with buprenorphine is a legitimate medical treatment that saves lives, reduces overdose mortality, and improves quality of life. At Keystone Health Group, we support evidence-based treatment without stigma.

Signs & Symptoms of Addiction

Opioid use disorder diagnosis

History of opioid overdose

Multiple failed attempts at abstinence-based treatment

High relapse risk

Co-occurring chronic pain

Desire to engage in MAT

Fentanyl use disorder

Heroin use disorder

Our Treatment Approach

Physician-directed buprenorphine induction and dosing

COWS monitoring to guide induction timing

Short-term detox taper or long-term maintenance options

Integration with behavioral therapy

Regular monitoring and dose adjustment

Transition planning for ongoing MAT after discharge

Frequently Asked Questions

Is Suboxone the same as Zubsolv?

Both contain buprenorphine and naloxone but differ in formulation. Zubsolv is a sublingual tablet with higher bioavailability, meaning a lower dose delivers the same effect. The choice between them is made by our physicians based on clinical factors and patient preference.

How long do I need to take buprenorphine?

Research shows that longer duration of MAT produces better outcomes. The appropriate duration varies by individual. Our physicians work with each client to determine the right approach — from short-term detox support to long-term maintenance.

Does insurance cover Suboxone/Zubsolv treatment?

Yes. Most major insurance plans cover MAT with buprenorphine under behavioral health and/or pharmacy benefits. Our admissions team verifies your coverage for free.

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