The NSS-2 Bridge: Opioid Withdrawal Relief at Keystone Health Group
FDA-cleared neurostimulation technology that significantly reduces opioid and other withdrawal symptoms — a non-opioid option available at Keystone Health Group in Los Angeles.
The NSS-2 Bridge is an FDA-cleared percutaneous nerve field stimulator (PNFS) device that has been shown to significantly reduce the symptoms of opioid withdrawal. Worn behind the ear, it delivers gentle electrical stimulation to specific cranial nerve branches that modulate the body's withdrawal response. At Keystone Health Group, the NSS-2 Bridge is available as part of our medical detox program — offering patients a non-opioid option for managing withdrawal discomfort.
How the NSS-2 Bridge Works
The NSS-2 Bridge device is a small, battery-powered neurostimulator that is placed behind the ear and secured with adhesive. It delivers low-level electrical pulses to branches of the auricular (ear) cranial nerves — specifically the vagus nerve, the glossopharyngeal nerve, and the facial nerve. These nerves have connections to brain regions involved in the stress response and autonomic nervous system regulation. By modulating these pathways, the NSS-2 Bridge reduces the intensity of withdrawal symptoms including anxiety, sweating, nausea, muscle aches, and insomnia.
Clinical Evidence
The NSS-2 Bridge received FDA clearance in 2017 for use as an aid in the treatment of symptoms of opioid withdrawal. Clinical studies have demonstrated significant reductions in withdrawal severity scores (COWS — Clinical Opiate Withdrawal Scale) in patients using the device compared to controls. In one study, patients using the NSS-2 Bridge showed an average 88% reduction in withdrawal symptoms within 30 minutes of device activation.
Who Is the NSS-2 Bridge For?
The NSS-2 Bridge may be particularly appropriate for patients who: prefer a non-opioid approach to withdrawal management, are not candidates for buprenorphine (Suboxone/Zubsolv), are undergoing detox from opioids and want to minimize the use of additional medications, or are experiencing withdrawal from multiple substances. Our physicians assess each patient individually to determine whether the NSS-2 Bridge is appropriate as a standalone treatment or in combination with other medications.
The NSS-2 Bridge and Medication-Assisted Treatment
The NSS-2 Bridge can be used alone or in combination with other medications. In some cases, it may reduce the need for buprenorphine or other medications during detox. In other cases, it is used alongside MAT to provide additional symptom relief. Our physicians work with each patient to design the most appropriate and effective detox protocol.
Common Withdrawal Symptoms
How We Treat It
Frequently Asked Questions
Is the NSS-2 Bridge FDA-approved?
The NSS-2 Bridge is FDA-cleared (510(k) clearance) as a percutaneous nerve field stimulator for use as an aid in the treatment of symptoms of opioid withdrawal. FDA clearance means the device has been reviewed and found to be substantially equivalent to a legally marketed predicate device.
Does the NSS-2 Bridge hurt?
Most patients describe the sensation as a mild tingling or buzzing behind the ear. The stimulation level is adjustable, and our clinical staff ensure that the device is set to a comfortable level for each patient.
How long is the NSS-2 Bridge worn?
The NSS-2 Bridge is typically worn for 5 days during the acute withdrawal period. It is a disposable device that is replaced as needed.
Can the NSS-2 Bridge be used for alcohol or benzodiazepine withdrawal?
The NSS-2 Bridge is FDA-cleared specifically for opioid withdrawal. Some clinicians have used it off-label for other withdrawal syndromes, but the primary evidence base is for opioid withdrawal. Our physicians will discuss whether it is appropriate for your specific situation.
Does insurance cover the NSS-2 Bridge?
Coverage for the NSS-2 Bridge varies by insurance plan. Our admissions team will verify your benefits and discuss the options available to you before admission.
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Same-day admissions available. Most insurance accepted.