Oxycodone & Hydrocodone Detox in California
Medically supervised detox for OxyContin, Percocet, Vicodin, Norco, and other prescription opioids at Keystone Health Group in Los Angeles.
Oxycodone (OxyContin, Percocet) and hydrocodone (Vicodin, Norco) are among the most commonly misused prescription opioids in the United States. Physical dependence can develop even in patients taking these medications as prescribed, and withdrawal can be intensely uncomfortable. At Keystone Health Group, our medical team provides individualized, compassionate detox protocols for prescription opioid dependence — with medication-assisted treatment options to minimize withdrawal discomfort.
Oxycodone vs. Hydrocodone: What's the Difference?
Both oxycodone and hydrocodone are semi-synthetic opioids that work by binding to mu-opioid receptors in the brain and body. Oxycodone (found in OxyContin, Percocet, Roxicodone) is slightly more potent than hydrocodone (found in Vicodin, Norco, Lortab). Both produce similar withdrawal syndromes, and both are treated with the same evidence-based detox protocols at Keystone Health Group.
How Prescription Opioid Dependence Develops
Prescription opioid dependence can develop in two ways: through misuse (taking more than prescribed, using someone else's prescription, or using for non-medical purposes) or through physical dependence that develops even with therapeutic use. In both cases, the body adapts to the presence of the opioid and produces withdrawal symptoms when the drug is reduced or stopped. This physical dependence is not the same as addiction, but it requires medical management.
Medication-Assisted Treatment for Prescription Opioid Detox
Our physicians use buprenorphine (Suboxone, Zubsolv) and/or the NSS-2 Bridge device to manage prescription opioid withdrawal. Buprenorphine is a partial opioid agonist that reduces withdrawal severity and cravings without producing the euphoria of full opioid agonists. Clonidine may also be used to manage autonomic withdrawal symptoms such as sweating, elevated heart rate, and anxiety.
Extended-Release Formulations
Extended-release oxycodone formulations (OxyContin) have a longer duration of action than immediate-release formulations, which can affect the withdrawal timeline. Our physicians account for the specific formulation and dose when designing your detox protocol. The goal is always to minimize withdrawal severity while ensuring medical safety.
Common Withdrawal Symptoms
How We Treat It
Frequently Asked Questions
How long does oxycodone or hydrocodone withdrawal last?
Withdrawal from immediate-release oxycodone or hydrocodone typically begins 8–24 hours after the last dose, peaks at 36–72 hours, and resolves within 5–7 days. Extended-release formulations may produce a slightly delayed onset and prolonged course.
Can I become dependent on oxycodone even if I take it as prescribed?
Yes. Physical dependence can develop with regular use of opioids even when taken exactly as prescribed. This is a physiological adaptation, not a moral failing. If you have developed physical dependence, medical detox provides a safe and compassionate path to discontinuing the medication.
Is Suboxone used during prescription opioid detox?
Yes. Buprenorphine (Suboxone, Zubsolv) is FDA-approved for opioid withdrawal management. It significantly reduces withdrawal severity and cravings. Our physicians determine whether buprenorphine is appropriate based on your specific situation.
Does insurance cover prescription opioid detox?
Yes. Most major insurance plans cover medically necessary opioid detox under behavioral health benefits. Our admissions team verifies your coverage for free before admission.
Ready to Start Detox?
Same-day admissions available. Our team is here 24/7.
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Same-day admissions available. Most insurance accepted.